Cov teebmeem ntawm kev rog rog ntawm kev noj qab haus huv ntawm lub cev, nrog rau cov txiaj ntsig ntawm kev poob phaus, paub zoo. Poob 5-10% ntawm koj lub cev qhov hnyav tuaj yeem txo qhov kev pheej hmoo ntawm hom 2 mob ntshav qab zib mellitus thaum tseem txhim kho cov kev pheej hmoo cardiometabolic (xws li kub siab) thiab lwm yam teeb meem kev rog rog (xws li osteoarthritis).
Kev cuam tshuam kev ua neej hnyav tau raug pom zoo los ua ib txoj hauv kev los tswj kev rog, suav nrog txo qis calorie kom tsawg thiab ua kom muaj zog. Tab sis nws txoj kev ua tau zoo tag nrho yog txwv los ntawm ob yam. Ua ntej, qhov kev poob phaus ntawm kev ua neej nyob yog qhov nruab nrab, nrog tsawg dua 20% ntawm cov neeg tuaj yeem poob ntau dua 15% ntawm lawv qhov hnyav. Qhov thib ob, kev poob phaus ua tiav los ntawm kev cuam tshuam kev ua neej feem ntau rov qab ib feem peb ntawm lub cev qhov hnyav hauv ib xyoos thiab maj mam rov qab los ntawm lub sijhawm.
Hauv xyoo tas los no, cov tshuaj poob phaus tshiab raws li GLP-1 receptor agonists tau pom zoo rau kev lag luam, uas tuaj yeem txhawb nqa cov txiaj ntsig ntawm kev cuam tshuam kev ua neej hnyav. Semaglutide yog GLP-1 receptor agonist tsim los ntawm Novo Nordisk thiab tau pom zoo rau kev tswj hwm hom 2 mob ntshav qab zib thiab poob phaus. Hauv cov neeg uas rog dhau lossis rog tab sis tsis muaj ntshav qab zib, semaglutide tuaj yeem txo lub cev hnyav li 15% txog li 2 xyoos (piv rau 2-3% rau cov placebo). Semaglutide txo qis qab los noj mov feem ntau los ntawm kev hloov cov kev tshaib kev nqhis thiab satiety teeb liab hauv cov neural tshwj xeeb, yog li txo qis caloric kom tsawg.
Tizepatide yog cov tshuaj tshiab tsim los ntawm Eli Lilly thiab Tuam Txhab. Nws yog kev sib xyaw ua ke ntawm cov piam thaj-dependent insulinotropic polypeptide (GIP) receptor thiab glucagon-zoo li peptide -1 (GLP-1) receptor. Agonists uas tsim kev sib koom ua ke ntawm kev qab los noj mov, caloric kom tsawg, thiab metabolic muaj nuj nqi. Nws tau raug pom zoo rau kev tswj hwm hom 2 mob ntshav qab zib hauv Tebchaws Meskas, European Union, Nyij Pooj thiab lwm thaj chaw, thiab tau raug tshuaj xyuas los siv los ua tshuaj poob phaus.
Cov txiaj ntsig tau los ntawm theem 3 kev sim tshuaj hu ua SURMOUNT-1 tso tawm xyoo tas los pom tias cov neeg rog rog lossis rog dhau tab sis tsis muaj ntshav qab zib poob 20.9% ntawm lawv lub cev qhov hnyav (placebo) tom qab 72 lub lis piam kho mob (15 mg txhaj ib zaug. ib lub lim tiam). 3.1% hauv pawg tshuaj), nrog rau kev txo qis hauv kev pheej hmoo cardiometabolic.
Pab pawg kws tshaj lij qhia tias kev siv tshuaj poob phaus tom qab kev cuam tshuam kev ua neej hnyav tuaj yeem ua rau poob phaus ntxiv lossis tsawg kawg tiv thaiv qhov hnyav dua.
Thaum Lub Kaum Hli 15, 2023, Eli Lilly thiab Tuam Txhab, ua ke nrog cov kws tshawb fawb tshawb fawb los ntawm University of Pennsylvania thiab lwm lub koom haum tshawb fawb, luam tawm ib daim ntawv nyob rau saum toj kawg nkaus thoob ntiaj teb kev kho mob phau ntawv journal Nature Medicine muaj cai: Tirzepatide tom qab kev cuam tshuam kev ua neej nyob rau cov neeg laus uas rog dhau lossis rog. : SURMOUNT- Phase 3 soj ntsuam cov ntaub ntawv tshawb fawb ntawm theem 3 mus sib hais.
Cov txiaj ntsig tau los ntawm theem 3 kev sim tshuaj ntsuam xyuas, SURMOUNT-3, tau qhia tias kev kho mob nrog Tizepatide rau 72 lub lis piam tau ua raws li 12 lub lis piam ntawm kev cuam tshuam kev ua neej, suav nrog kev noj zaub mov tsawg, kev tawm dag zog thiab kev tawm tswv yim nquag. Tshaj tag nrho ntawm 84 lub lis piam, cov neeg koom nrog rog lossis rog tab sis tsis muaj ntshav qab zib poob qhov nruab nrab ntawm 26.6% (29.2kg) ntawm lub cev hnyav, piv nrog tsuas yog 3.8% (4.1kg) hauv pawg placebo.
Hauv theem 3 kev soj ntsuam, SURMOUNT-3, tag nrho ntawm 806 tus neeg koom, uas pib nrog qhov hnyav nruab nrab ntawm 109.5 kg, yog cov neeg laus rog rog lossis rog rog yam tsis muaj ntshav qab zib hauv 12- lub limtiam pilot txoj kev ua neej. Thaum kawg ntawm lub sijhawm, uas suav nrog kev noj zaub mov tsawg, kev tawm dag zog thiab kev tawm tswv yim nquag, 579 cov neeg koom tau poob 5% lossis ntau dua ntawm lawv lub cev hnyav. Lawv tau poob qhov nruab nrab ntawm 6.9% (7.6kg) ntawm lawv lub cev hnyav. Tom qab ntawd lawv tau muab tso ua ke kom tau txais cov placebo lossis Tizepatide kev kho mob kav ntev li 72 lub lis piam, nrog rau koob tshuaj pib ntawm 2.5 mg thiab nce ntxiv 2.5 mg txhua plaub lub lis piam mus txog rau qhov siab tshaj plaws (10 mg lossis 15 mg).
Cov txiaj ntsig tau pom tias cov neeg koom nrog poob qhov nruab nrab ntawm 21.1% ntawm lawv qhov hnyav thaum 72 lub lis piam ntawm kev kho Tizepatide. Thiab lawv poob qhov nruab nrab ntawm 26.6% (29.2 kg) ntawm lub cev hnyav hauv tag nrho 84 lub lis piam txij thaum pib ntawm txoj kev tshawb no. Qhov no kuj yog qhov zoo tshaj plaws tshuaj yuag poob cov nyhuv tam sim no ua tiav hauv kev sim tshuaj. Cov pab pawg placebo poob qhov nruab nrab ntawm 26.6% hauv qhov hnyav hauv 84 lub lis piam. 3.8% sib dua (4.1 kg).
Tag nrho cov ntaub ntawv kev nyab xeeb ntawm Tizepatide hauv Phase 3 qhov kev sim tshuaj no zoo ib yam li cov kev sim tshuaj yav dhau los. Cov xwm txheej tsis zoo tshaj plaws yog kev mob plab hnyuv thiab feem ntau mob me mus rau nruab nrab ntawm qhov hnyav. Piv nrog rau cov placebo, feem ntau tshwm sim tsis zoo nyob rau hauv pab pawg neeg kho Tizepatide yog xeev siab (39.7% vs. 14.0%), raws plab (31.0% vs. 9.2%), cem quav (23 .{{10}}% vs. 6.8%), COVID -19 (23.0% vs. 25.3%) thiab ntuav (18.1% vs. 1.4%). Cov xwm txheej tsis zoo ua rau tsis muaj kev tshawb fawb txog kev kho mob hauv 10.5% ntawm cov neeg koom hauv pawg Tizepatide thiab 2.1% ntawm cov neeg koom nrog cov placebo.
Dr. Jeff Emmick, tus lwm thawj coj loj ntawm kev tsim khoom lag luam ntawm Eli Lilly thiab Tuam Txhab, tau hais tias hauv txoj kev tshawb no, cov neeg uas tau noj Tizepatide tom qab kev cuam tshuam tau muaj kev txhim kho tseem ceeb thiab ntev ntev hauv lawv txoj kev sib raug zoo nrog kev noj haus thiab kev tawm dag zog ntau dua li cov neeg uas tau noj cov tshuaj. placebo tom qab kev cuam tshuam. poob phaus. Txawm hais tias kev cuam tshuam hauv kev ua neej hnyav yog ib qho tseem ceeb ntawm kev tswj hwm kev rog, qhov kev sim tshuaj ntsuam xyuas no qhia txog qhov nyuaj rau qee cov neeg muaj kev tswj kom poob phaus nrog kev noj haus thiab kev tawm dag zog ib leeg.
