Tianeptine alleviates cov tsos mob ntawm kev nyuaj siab xws li mus ob peb vas thiab ncua kev xav los ntawm kev tswj cov neurotransmitter tshuav nyiaj li cas, tshwj xeeb tshaj yog los ntawm kev nce qib ntawm serotonin (5-HT) thiab norepinephrine (NA). Nws tsuas yog ua rau ntawm 5-HT system, nce kev nce ntawm 5-HT hauv synaptic cleft thiab muaj peev xwm txhim kho kev sib kis ntawm 5-HT neurons, yog li ua tiav cov tshuaj tiv thaiv kev nyuaj siab.Thiamethasone kuj muaj lwm yam. teebmeem. Piv txwv li, nws tuaj yeem ua kom ntev ntev ntawm kev pw tsaug zog, txo lub sijhawm latency kom tsaug zog, txo tus naj npawb ntawm kev pw tsaug zog thaum hmo ntuj, thiab yog li pab txhim kho cov tsos mob insomnia. Tsis tas li ntawd, cov kev tshawb fawb tau pom tias tianeptin tuaj yeem cuam tshuam kev tsim khoom thiab sib sau ua ke ntawm - amyloid protein, uas yuav muaj peev xwm ua kom qeeb ntawm kev mob Alzheimer's.
Puas yog tianeptine nce dopamine?
Tianeptine tsis nce dopamine. Cov hauv qab no yog cov lus piav qhia ntxaws txog qhov xaus no:
Tianeptine yog ib qho kev xaiv 5-HT (5-hydroxytryptamine) uptake enhancer uas feem ntau ua rau ntawm 5-HT system. Nws tswj hwm 5-HT muaj nuj nqi los ntawm kev txhawb nqa rov qab ntawm 5-HT hauv synaptic cleft. Cov txheej txheem ntawm kev txiav txim no tsis ncaj qha cuam tshuam rau lub dopamine system.
In addition, studies have shown that Tianeptine has no affinity for multiple receptors, including receptors such as 5-HT and dopamine (IC50>10 μ M), uas txhais tau hais tias nws tsis ncaj qha ua rau cov receptors cuam tshuam rau neurotransmitter tso tawm lossis uptake. Yog li, raws li cov ntaub ntawv tshawb fawb uas twb muaj lawm, Tianeptine tsis nce qib dopamine.
Nws yuav tsum raug sau tseg tias cov txheej txheem ntawm kev txiav txim ntawm cov tshuaj yuav koom nrog ntau yam txheej txheem physiological thiab biochemical, thiab tej zaum yuav muaj qhov sib txawv ntawm tib neeg. Yog li ntawd, txawm hais tias Tianeptine tsis nce dopamine, nws yuav muaj lwm yam kev ua haujlwm hauv cov tshuaj tiv thaiv kev ntxhov siab, tiv thaiv kev ntxhov siab, thiab lwm yam, xws li stimulating μ - opioid receptors, δ - opioid receptors, thiab indirectly tswj NMDA receptors, AMPA receptors, thiab lwm yam.
Hauv cov ntsiab lus, Tianeptine tsis nce dopamine, thiab nws cov tshuaj pharmacological xws li tshuaj tiv thaiv kev ntxhov siab thiab kev ntxhov siab tuaj yeem ua tiav los ntawm lwm cov txheej txheem. Thaum siv Tianeptine, ib tug yuav tsum ua raws li tus kws kho mob cov lus qhia thiab kev taw qhia kom muaj kev nyab xeeb thiab ua tau zoo.
