Nad yog dab tsi?
Nad muaj nyob rau hauv ob interconvertibertibre: nad⁺ (oxidized) thiab nadh (txo). Qhov no redox khub yog qhov tseem ceeb rau nws lub hom phiaj tseem ceeb ua ib qho khoom siv hydride, shutting hluav taws xob los ntawm ib qho molecule mus rau lwm tus hauv cov kev metabolic. Kev tsim qauv, nws yog tsim ntawm ob lub nucleotides koom los ntawm lawv pawg phosphate: ib lub nucleotide cov yam ntxwv adenine puag, thiab lwm lub qhov nicotinamide puag. Cov vitamin B3 Tsev Neeg (Niacin, Nicotinamide, thiab Nicotinamide Riboside) Ua haujlwm yog cov noj mov tseem ceeb ntawm cov khaws cia thiab prech {4 4 4}} Txoj kev tuav tes. Lub cev ntawm cov nad⁺ yog kev tswj hwm los ntawm nws cov kev noj los ntawm ntau cov enzymes, ua nws cov hluavtaws tseem ceeb rau kev noj qab haus huv ntawm tes.
Tus cwj pwm tseem ceeb ntawm nad hauv lub cev
Nad lub luag haujlwm txuas mus deb dhau ntawm nws lub luag haujlwm ntawm lub zog metabolism hauv lub zog.
1. Lemgy ntau lawm: Nad⁺ yog lub koom hluav taws xob tseem ceeb hauv catabolism ntawm cov as-ham, suav nrog cov piam thaj, fatty acids, thiab cov amino acids. Nws raug txo kom nadh hauv cov txheej txheem xws li glycolysis thiab cov citric acid voj voog. Nadh mam li pub nws cov hluav taws xob rau mitochondrial electron thauj saw, tsav tsheb tsim ntawm adenosine triphosphate (ATP), lub xovtooj ntawm tes txiaj.
2.Celular Kws Muaj Txuj Ci thiab DNA kho: Nad⁺ ua raws li cov txheej txheem tseem ceeb rau chav kawm ntawm enzymes hu ua poly (adp- ribose) polymerases (morps). Parps tau nrawm nrawm los ntawm DNA kev puas tsuaj thiab pab txhawb kev kho DNA los ntawm kev ntxiv adteins rau cov hom proteins, cov txheej txheem uas siv cov khoom tseem ceeb ntawm Nad⁺. Kev kho DNA tau zoo yog qhov tseem ceeb rau cov kev ruaj khov thiab kev tiv thaiv mob qog noj ntshav.
3.regulation ntawm kev laus thiab ntev: Tej zaum feem ntau tshawb nrhiav lub luag haujlwm ntawm cov shaluins, tsev neeg ntawm nad⁺ {1 - 7 hauv cov tsiaj txhu). Sirtuins tau koom nrog cov txheej txheem tseem ceeb xws li gene kev tawm, kev ntxhov siab tiv thaiv, metabolism tsis kam, cov metabolism, thiab cov ntsej muag ci ntsa iab. Lawv cov haujlwm tau sib txuas tau zoo sib txuas rau kev ua kom ntev ntev, thiab poob qis hauv cov qib Nad⁺ nrog cov hnub nyoog muaj kev cuam tshuam nrog ntau yam kab mob los ntawm kev txo qis sirtin kev ua si.
4.Calcium kos npe thiab kev tiv thaiv kab mob: Nad⁺ tseem yog ib qho tseem muaj kev ua kom muaj CD38 thiab CD157, ecolyzymes uas hydrolyze nad⁺ los tsim calcium {}} mob rau cov neeg xa xov thib ob. Cov enzymes no yog cov tswj hwm loj ntawm NADUN qib hauv lub cev thiab ua si lub luag haujlwm tseem ceeb hauv kev tiv thaiv kev tiv thaiv ntawm tes thiab kev kos npe.
Leej twg sawv kom tau txais txiaj ntsig?
Cov qib ntuj poob ntawm cov qib nad⁺ cuam tshuam nrog kev laus tau spurred txaus siab nyob rau hauv nad⁺ ntxiv rau kev tawm tsam hnub nyoog {}}}} cov pathologies. Thiaj li, ntau pab pawg yuav muaj feem muaj txiaj ntsig los ntawm cov tswv yim los txhawb nqa Nad⁺:
1. Sau rau cov neeg: Cov tib neeg nrhiav kev txo qis lub hnub nyoog {}} kev ua haujlwm poob rau hauv lub zog ntawm cev, thiab cov kev ua haujlwm metabolic, thiab kev ua haujlwm metabolic yog lub hom phiaj tseem ceeb. Cov kev tshawb fawb preclinical thiab thaum ntxov tau hais tias NADA ua ntej yuav pab txhawb mitochondrial muaj nuj nqi thiab txhim kho ntawm kev noj qab haus huv.
2. Dindeguals nrog cov teeb meem metabolic: Muab Nad⁺ lub luag haujlwm tseem ceeb hauv kev ua ntshav qab zib, nrog kev tshawb fawb hom kev mob ntshav qab zib, thiab tsis muaj peev xwm ua cov peev xwm, thiab cov khoom muaj txiaj ntsig hom 2.
3.Nawv noj qab haus huv: Tshawb nrhiav yog qhov muaj peev xwm tshawb nrhiav cov kab mob nad⁺ hauv nurodegenering thiab Alzheimer's thiab Oxidative kev nyuaj siab yog qhov tseem ceeb. Nws kuj tseem tuaj yeem pab txhawb kev txawj ntse thiab cov neuronal resilisence.
4.Thaum thiab tus neeg hlub muaj zog: Nad⁺ yog qhov tseem ceeb rau cov leeg ua haujlwm thiab rov qab. Qee cov pov thawj qhia tau tias kev txhawb nqa nrog Nada prefursors yuav txhim kho kev ua haujlwm thiab txo kev qaug zog los ntawm kev txhim kho mitochondrial efficiency.
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Peb xi'an herben biological Technology Co., Ltd yog cov khoom lag luam peptide hauv xi'an los ntawm Tuam Tshoj.Peb muab kev coj dawb huv siab thiab zoo retatrutide. Koj tuaj yeem tshawb xyuas peb Daim Ntawv Pov Thawj COA raws li hauv qab no:
